Returning to London for a second year, the Los Angeles Rams take on the Arizona Cardinals at Twickenham Stadium.
Following their defeat at Twickenham last year, do the Los Angeles Rams and their renowned running back Todd Gurley have what it takes to claim victory against the Arizona Cardinals, who boast legendary wide receiver Larry Fitzgerald and running back David Johnson in their ranks? With both teams belonging to the NFC West division, expect heated rivalry in this exciting divisional clash - only the third of its kind to be played in London.
This is the third of four NFL London Games this September and October, featuring extraordinary sport and entertainment at Wembley and Twickenham Stadiums.
To learn more about the NFL take a look at the Rookie Guide.